special medical approach

Recently, more disputes as to whether, when it is better to give birth - in 20-25 years or after 35. Business lady, of course, prefer first to get an education, a career, establish a business, to ensure the financial stability of the family, and only then - year to 40 - acquire offspring.



I recall that before the past 30 years, women were considered starorodyaschimi, and apply to them, as a rule, a special medical approach and greater attention. On the other hand, in 2008 in India completely without complications gave birth to twins 70-year-old Omkar Panvar.



However, doctors believe this case is no exception. After all, the female body is designed so that the ability to conceive an egg laid in it even at conception. And, accordingly, no further updates, and grow old together with a woman. Also, the number of abnormal chromosomes, which change occurs under the influence of stress and diseases of the female organism.



However, experts say that modern medicine is easily capable of all these problems to handle. Currently, the number of young women in childbirth equal to the number of ladies who are going to give birth as early as middle-aged.



And for young women, pregnancy - is another way to ride out the crisis, saving work. Whereas for women after 35 - this is a balanced, planned, and, sometimes, the long-awaited step. In doing so, we Xeloda must not forget that no matter what age you decide to have children, particularly important is your desire and your commitment for this important case.



Folk wisdom says that the late pregnancy - a fortune by suffering. Therefore, doctors warn that carrying a child into adulthood may run processes that will accelerate the development razed disease in women. But, as stipulated the same experts, the risk does not depend on the age of the woman. Indeed, some young mothers have more disorders than their male counterparts.



The only thing to remember, became pregnant after 35 years - the need to promptly carry out detailed studies of the fetus and in time to take the necessary tests. And also try to feel less nervous and always be in a good mood. Especially since this will not only happy with the future kids, but will save yourself from all sorts of complications and stress.

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ten percent

Scientists already know how to win the majority of ailments, but so far can only do so in vitro.


Mythical Philosopher's Stone had the property not only to turn into gold everything, but to give the owner of eternal youth. A century later, it turned out that this is not such a utopia. However, current approaches to the problem of prolonging life is as different from the medieval Tibetan Herbal Massage as modern biotechnology on alchemical experiments. Be that as it may, today, science is on the verge of great discoveries. And there is hope that in the coming years - the maximum decades - scientists will be ready to hand shaken humanity panacea - a cure for all (well, almost all) of disease. A kind of philosopher's stone of our days.



Search and Destroy

In an ordinary person such a statement would only unbelieving smile - what kind of panacea may be involved, if not yet even invented a cure for banal flu? Antipyretics and immunomodulating not count.

And here you are mistaken. The tool, in fact, already have. The fundamental formula is known, above him a long way with scientists from the Institute of Chemical Biology and SPA World Fundamental Medicine, SB RAS. However, when finished tablets reach real patients - still a big question. But it is already clear that the direction is very promising, promising a lot of success and victories.

Strictly speaking, it is clear this was not today and not yesterday. Nearly forty years ago, the institute had not yet Academician Dmitry Knorre and a leading chemist in his laboratory Nina Grineva The use of flax in Spa have begun to develop methods for the synthesis of nucleic acids to influence with their help on intracellular processes. The selected area was not just a promise, but a breakthrough. At the turn of the XXI century scientists managed to peek Spa treatment kingdom of underwater depth into the inner sanctum of nature - the internal structure of the gene. And not only look, but fundamentally there pohozyaynichat.

- If a physicist declared a priority area of research on the scale "nano" has been new and maloizvedannoy, for us, molecular biologists, is a world quite familiar, - the director IHMFM Academician Valentin Vlasov. - We have always worked with nano-objects, as DNA, proteins, cells, viruses, bacteria, which constitute the scope of our interests, just have a nanoscale. What we are doing more than twenty years, except Bionanotechnology not name.

Today, scientists are able to build chains of nucleotides (called oligonucleotides) - synthetic analogs of fragments of natural DNA and RNA. Already have special machines - so-called DNA synthesizers that "slander" chain predetermined structure and length. Incidentally, the only Russian manufacturer of such machines - the company "Biosset" - is in Novosibirsk Akademgorodok. It not only provides all the synthesizers national science, but also exports these devices in two dozen foreign countries - from U.S. to Malaysia.

As is known, natural oligonucleotide is able to find and recognize their complementary counterparts. Two chains are suitable to each other, as the key to the castle, and the same, like two halves of a zipper. Similarly behaves a synthetic oligonucleotide. This property of the Spa in the Beauty Salon scientists decided to use to combat the pathogens of various ailments. Let the synthetic nucleic acid will be weapons, and a fragment of a hostile genes - the target. We construct the desired chain, run it in the free search - and she finds and infects a given goal. It turns out that, in principle, can create a cure for practically any disease - from viral infections to cancer and genetic abnormalities.

This method was called antisense technology, and in due time stirred up the entire global biological community. It seemed - there it is, panacea, universal remedy for all ills. However, the reality was far more complicated - that took shape on paper and worked in vitro, in vivo was faltering and complications.

- Synthesize oligonucleotides of a given length and structure, we are able. Problems are not here, - said the deputy director ICBFM Ph.D. Dmitry Lush. - The problem is - how to deliver our "weapons" in a cage. The nature itself is protected from any cell of foreign intervention, from any alien nucleic acids. Overcoming these barriers - a very difficult task.



Influenza to cancer

Today, members of the Institute (as do their counterparts around the world) are looking for ways to cheat nature and smuggle the synthetic nucleotide across the cell membrane by hiding it inside the nanoparticles. For these purposes, typically use harmless lipids. Once inside the SPA therapy cell and released from the lipid camouflage nucleotide can "shoot" and hit the malicious gene. In ICBFM SB RAS those problems involved in the laboratory of Dr. Marina biology Zenkova. Scientists have found several promising options nanoparticles.

However, to solve the problem of transport drugs into the cell - this is half the battle. It is important not to cause harm to the body - that delivered the hard-drug, as sometimes happens, does not turn into poison. Who knows how to behave fragments created by human DNA-containing structures - where they then want to surprise the researcher to fit into and what side effects cause. The body - no tube, here all processes are much more complicated and less predictable.

With these and similar problems faced scientists towards a "cure-all. But happen along the way and unexpected discoveries. Suddenly it turns out that a certain compound gives a unique biological effect - and it can patent a new drug is effective.

It was so notorious and found a cure for influenza. Employees of the institute have found chemical groups capable of The concept of Spa-zone destroying the RNA - literally tearing it apart. Developers Marina Zenkov and her colleague Dr. Vladimir Chemistry Silnikov implied connect these groups to oligonucleotides to cleave and inactivate RNA target. But it turned out that by themselves, these compounds can be used as drugs - including, to combat influenza.

I must say that the influenza virus genome consists entirely of RNA (as opposed to the human genome). The obtained compound behaves very curious: it destroys the genetic information of the virus, and the virion remains intact and seemingly unharmed. He can no longer multiply, can cause fever, runny nose and other customary for flu symptoms. On the other hand is able, once in the body to initiate an immune response - roughly speaking, to act as a kind of inoculation. So scientists have received drugs and vaccines in the literal sense in one bottle.

- Potentially, we are able today to settle any molecular cellular processes involving nucleic acids, - says Dmitry Lush. - It means almost endless possibilities for therapy.

And if earlier it was believed that oligonucleotides in the antisense technology has the potential to affect only the genetic material, it is now clear that the nucleic "weapons" can be used to "hunt" on virtually any harmful compounds - as low molecular weight (drugs, poisons), and macromolecular (proteins, viruses).

The fact that the oligonucleotide chain can not only communicate with the complementary fragment, but also install the interatomic bonds within itself, taking a variety of spatial forms. And if there is a corresponding form of this molecular target, such an oligonucleotide recognizes her, seize and deprive the way of activity. Now there technologies selection of furnished space polymers (aptamers), aimed at specific types of ligands. Take a target molecule, and poured her a pool of various nucleic acids. Some of them are fixed, the remaining swaps, biologists isolate the desired form and copy - and here we are, ready to biological weapons against another enemy.

- Creation of aptamers and other variants of antisense technology - all this is very promising, - says Dmitry Lush. - We already have a number of interesting patents - just take the same remedy against influenza. Why it does not reach practical application? The problem is the absence of an interested Chemical Peels customer in the face of pharmaceutical companies. The task of scientists - to multiply the scientific knowledge that we are doing. Will the real order and appropriate funding - we are ready to make our developments in specific products.



How are you? Presentation of your passport!

If the drugs based on antisense technology, there are still only in idea, in theory, in vitro, the molecular diagnosis has already used extensively. The principle is generally the same: there is a so-called markers - proteins or genetic information, which must find and recognize, and there is a certain connection (probe), which will be able to do it. A probe that was simpler, using polymerase chain reaction. This is the same all the known PCR-diagnostics, which is now used in all clinical laboratories.



Infection with tick-borne encephalitis, tuberculosis or other serious infections defined as the time in this way. The idea is to increase the authenticity strictly defined fragments of genetic material. One molecule of "detect" almost impossible, but when these molecules will be a million, here the probe is not exactly miss.
Now scientists all over the world and the Institute of Chemical Biology, in particular looking for molecular markers for each disease and the related compounds-probes. Of course, the hottest The direct road to a beautiful belly topic today - oncology. How to find just one specific piece of DNA, which determines that it is - really cancer or other ailment? And if cancer, breast, stomach or intestines?

This is an incredibly complex, time-consuming task, requiring a great number of clinical trials. Especially when you consider that a reliable marker for the diagnosis of the same cancer is not enough. And in the case of multifactorial diseases - such as hypertension - is described not one, not five, not ten, but hundreds of markers and, therefore, hundreds of probes.

If you take a set of probes, we get a diagnostic chip. Ideology chip diagnosis among their first proposed and implemented by scientists from the Moscow Institute of Molecular Biology under the direction of his scientific research of academicians and Makarov. In their Siberian counterparts have their own know-how, for example, the latest sensational development of the laboratory of Alexander Sinyakova - unique in the world microchip, which determines all known strains of influenza type A, avian and swine to the usual seasonal viruses. Involved more than 300 probes, each - for credibility - clustered, that is repeated dozens of times, and all this "economy" on a small glass plate. An indispensable tool for epidemiologists and vivid example of Bionanotechnology.
Several years ago, the same laboratory in collaboration with SRC "Vector" has developed a chip for the determination of all types of smallpox. And their colleagues from the laboratory Bionanotechnology have the chip for analysis of different forms of hepatitis C. In the next two years should see a chip for detection of GMOs - genetically moditsifirovannyh organisms.

- Creation of such chips at our institute is already well-developed, - says Dmitry Lush. - And if tomorrow will come to us a scientist and say: Behold, I have 350 markers for such a disease, I need 350 probes - that our employees during the week will be able to design these probes, yet another week goes on the synthesis, oligonucleotides are then ready fix on a chip - and the resulting "set" can already be used for diagnosis.

At the same chip technology and gene-based diagnostics. Only if the usual chip, designed for the analysis of, say, the flu, contains hundreds of elements, in large, complex, analytical chips these elements - in the millions. Imagine: the patient delivers a few drops of blood for analysis and receives almost complete diagnostic picture - than he was ill, suffering from what is now and what risk disease in the future. It's called - Passport Health. Above the creation of such a universal diagnosticum scholars today still work, but some of the pages of the passport can be completed today.

- Are now known to thousands of genetic mutations, for which the exact connection is established with a specific disease. But that one single mutation defined a specific disease - what nature is rarely the case - says academician Vlasov. - Usually, mutations must be many - so that the remaining pages of the genetic passport we will in the coming years to fill and fill.


Games are played biologists

In 1990, biologists and geneticists voiced sensation: the world science is taken to decipher the human genome. Shared areas of work among leading countries, and began when - decoded five percent, ten percent, a quarter of the genome ... It was expected that the project will be completed within 15 years and will cost three billion dollars. However, the science behind it is time to step forward and plan failed prematurely.
Today the genome not only rights, but also bees, rice, wheat, Chinese panda bears and even a Neanderthal. Now they find out what different genetic information from people of different nationalities. Already, special machines - sequencers nucleic acids, which are read from the What is SPA? genes of the genome, both from an open book. While such machines are produced mainly in the U.S., but in the near future such a project will be launched in the SB RAS. Our scientists are hoping that the Siberian sequencers will be no worse than the imported equivalent.

The pace of development and achievements that demonstrate modern biotechnology, are stunning. Just over a quarter century ago, was opened polymerase chain reaction, for which its authors received the Nobel Prize. Today, PCR diagnosis has become quite an everyday occurrence, and is used in all laboratories. Twenty years ago, Russian scientist, Academician Andrei Mirzabekov put forward the idea of creating chips. Then it seemed impossible - now recognized as one of the 100 best inventions of the Millennium, and now chip technology booming around the world.

Another direction bionanotehnogy - creation of new materials. This is called DNA origami, - when the proteins and nucleic acids themselves fit into the space, forming different patterns, ribbons, intricate three-dimensional shapes. You can synthesize a chain that has evolved into a bird, a ball or even a word.

- It's not just an experiment for fun - explains academician Vlasov. - Applications of such structures can be the most unexpected. For example, in a certain way of coiled DNA obtained rough surface - a fee, which is convenient to fix the molecule-elements. And now we already have new material for microelectronics, and its nanoscale give a completely different possibilities.

In the near future at the Institute of Chemical Biology and Fundamental Medicine, will be worked out reliable methods of diagnosing breast cancer, pancreatic cancer, prostate. At the finish line comes a cure for influenza and a chip on genetically modified organisms. This is what scientists say is already a certainty.
But every year brings new discoveries and achievements. And now, apparently, molecular biology, on the verge of tremendous breakthroughs. While there is accumulation of knowledge, capabilities, ways of influence on the cell - so that later, in another ten years, "shoot" a great qualitative leap.

And it may very well be that in the end we really got a panacea - an absolute cure-all or almost certain ailments today, and the average human life will be longer with an extra couple of decades. It is true that scientists themselves prefer to talk about it with caution.

- Of course, everything depends not only on what doctors and biologists will be able to offer, but also on how the man himself would refer to himself, - says Dmitry Lush. - But in any case, we will live longer, better and healthier.

And in the end, as previously happened more than once, for a long time to fool nature unlikely. Surely she has in store for us new surprises - new and unknown ailments today, which has yet to face humanity. So relax not work. And the next generation of scientists, biologists and medical practitioners can find how to apply the talent and strength.

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The claim of India against the EU, in which the customs authorities of the European Union accused of illegal seizure of generic drugs, destined for Latin America and Africa, received the support of WHO, which characterize the actions of customs officers as inappropriate. As stated in canadian pharmacy Geneva, Director of WHO's program on vital medicines Hendrik Hogertsayl, European customs officials have no right to confiscate the transit Party generics under the guise that their manufacturers violated the patent rights.

More than a year, the customs authorities of the European camp, especially the Netherlands, seized or detained several batches of the Indian generic production.

India and Brazil have sent a protest against order levitra the actions of Customs officers on trade and diplomatic channels, stressing that there is a breach of international human rights.
Indian officials have held several rounds of talks with representatives of the EU, however, except for assurances that all violations are addressed, nothing.

alcohol testers

Swedish scientists have developed new methodology for determining the presence of drugs in the organism. Whereas existing methods require blood or urine test, the new method is very simple and consists in the analysis of exhaled air, just as checks of drivers with alcohol testers traffic cops around the world.

Through analysis of air exhaled by man is determined not only drunk drivers - in recent years, scientists have learned in such a way to diagnose asthma, diabetes and even certain types of cancer.

But researchers from the Swedish Research Center Karolinska Institutet have developed a method for rapidly and, most Vardenafil Drug By Bayer Pharmaceuticals importantly, very accurately determine the presence of the organism even small traces of drugs.

Scientists invited to participate in the study of volunteer addicts, who was hospitalized in a hospital in Stockholm with the symptoms of overdose of amphetamines. After some time, and after the patients began a normal feeling, the researchers asked the subjects to put on face masks and specially designed to be in them for 10 minutes. Then the masks Tadalafil Online Medicine - You Can! removed filters and subjected them to analysis by gas-liquid chromatograph and mass spectrometer. Instruments showed the presence of minute quantities of amphetamine, although since the last drug injection patients had passed a few weeks, and the traditional urine and blood samples were negative.

"These results are very promising. For the first time in the world we have created a technique allows to obtain very reliable data on the presence in the body of drugs. The compact device such as alcohol testers, but also to determine the drug in the exhaled air can be very useful for the police," - says Olof Beck, who led the study.

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It offers you a completely unacceptable situation - pretend that you agree and put forward the counter - which may not please him. Usually by a compromise can be minimized mutual inconvenience.

And most importantly - when all you have settled down you can always play their position and to regain lost it right. Just do not rush things!
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6. Speak only good. Do not remember if it your old quarrels, grievances, misunderstandings. It is much wiser to remember the good that has happened between vami.Takim way you yourself believe that it is a favorite led to believe that the happy days you have been much more than the bad.

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The joy of reconciliation can be clouded by the fact that, first proposed a "pipe of peace", you feel inferior and surrendered at discretion. But reconciliation is not in itself may be humiliating, so it is only your problem, how do you feel - the vanquished or victorious.

You'll have something to give him, but find mashonik his proposal rational and agreed with him. It wants you to change something in yourself? Listen to his advice - from the more obvious, and probably you, too, is not always satisfied with herself.

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That's me to the fact that your blagovernogo your ultimatum may cause just such a reaction. And then you have to either be consistent or go back down.

4. Did not suit hysterics - it's too powerful weapon, and they need to use extreme caution. Women's tears cause tenderness, tenderness and a desire to instantly shatter into a pancake only at the beginning of the novel. But after a while, they begin to be perceived merely as an unfortunate man, physiological feature of your body. At best, he'll regret and something tells a lie that only you would stop "Waterfalls". And at worst - just turn away, run away, throw up.
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What a mom will agree during the illness of his baby to have his antimicrobials stabbed intramuscularly, rather than simply be given medicine or tablets? Not every ... absolutely accurate. And why? Prevailing with a huge margin, most say: "Why should I hurt him, injections do ... when it is so convenient - a teaspoon to give medicine." And do not think my mother, how serious are the consequences of such reckless behavior. Although, why antibiotics immediately? There are lots of other diseases, conditions and medications that cause this problem. And not only for children ...

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Dysbacteriosis. About him, and should talk in mind the multiple epidemics of different diseases, as well as in connection with the enormous growth of the pharmaceutical industry.
What is' microflora 'and' disbacteriosis "?
Intestine for any of the readers MirSovetov no secret that in our body "live" a huge number of microorganisms, their over 490 species. But not all of them can and will cause various diseases. Therefore, there is pathogenic and conditionally pathogenic microflora. Generally, each person has his "people", their micro-organisms which in turn supports the body itself. That is a kind of symbiosis: "you - I, I - you."

developed a wide range

European researchers have created a new generation of semiconductor lasers, which will find their application in healthcare, telecommunications and instrumentation. The developers say the new lasers would help in detecting cancers in the creation of more high-speed broadband networks, as well as in the production of clearer displays.

The development of lasers is in the project Brighter, which co-financing deals with the European Union. Today, engineers have already conducted a first series of laboratory tests in which the lasers worked in the green, red and infrared spectra. Already, scientists have promised that their development will be applied in at least three branches.

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One of the most important areas of application development will create the installation, diagnose cancer in its earliest stages. It will be used so-called photodynamic therapy, which is more efficient and less harmful than the more common chemotherapy.


Photodynamic therapy works by introducing into the patient inactive chemotherapeutic drug, when it reaches the tumor, with the help of a new laser medicine is activated and affects only the area affected by cancer, healthy cells are unaffected.

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Now researchers have developed a wide range of lasers for a variety of elements. Thus, in the arsenal, there are two red laser with a wavelength of 635 and 650 nanometers - they are used to activate the different drugs. Meanwhile, the blue laser is a powerful fluorescent spectrographic setup. Finally, the infrared laser can create auto-flourestsentnye image area of the body, his cancerous.

Now a team of researchers from Europe to conduct clinical and practical tests and, if successful development will be commercialized.

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Moreover, the same researchers noticed that people with high levels of cholesterol in the blood rarely suffer various forms of dementia, including Alzheimer's disease.

It would seem contradictory information is obtained. A lot of cholesterol - good or bad? When the diagnostic capabilities of laboratory medicine grew, it became clear that cholesterol in its pure form in our bodies does not exist, that he has three sources and three component parts, drastically differing properties and functions.

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As a lipophilic substance ("zhirolyubivym") cholesterol in the blood plasma does not dissolved. Consequently, in order to be transported, require specialized protein-carriers. They are called apolipoprotein B, and complex "cholesterol + transport protein" is called a lipoprotein. These same lipoprotein distinguish three classes: HDL (high-density lipoprotein, HDL), LDL (low density lipoprotein, LDL) and VLDL (very low density lipoproteins, VLDL).
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HDL, which for strong facilitation sometimes called the "good" cholesterol, are readily soluble in water, does not tend to precipitate. They transport the cholesterol from the cells of various organs in the biochemical laboratory of the body - the liver. There is cholesterol converted into bile acids and excreted through the intestines.

LDL, which, again, for a strong simplification called "bad cholesterol", is the main transport form of cholesterol in the body. They carry cholesterol to cells of the body, as well as between cells. Poorly soluble in water and are not a good tendency to precipitate. This high level of LDL and is considered one of the major risk factors for atherosclerosis.

VLDL - rather motley group, which got everyone who did not have enough seats in the first two groups. Synthesized mainly in the liver, and their function - carry cholesterol and triglycerides from the liver to other organs. VLDL could be called "evil" cholesterol, because they take an active part in the formation of atherosclerotic plaques, and deservedly considered the most atherogenic lipoproteins.

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More than two thousand years ago in China, a group of scientists, among whom was Lao-tzu, was to seek true knowledge about the world. Their knowledge embodied in the various practices whose merits are not so long ago discovered and West (taychi, qigong, feng shui). These practices are based on faith in the fundamental life principle of qi. According to Tao, Qi circulates in the body, but also in the universe as a whole. This is the "breath", which allows you to connect to the cosmic forces. From the perspective of Chinese medicine disease occurs when a lack of qi in any organ. In this case, Chinese medicine recommends potent agent that affects even the most rational minds: having sex.
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To cure Chinese medicine recommends to have sex in a certain position at a certain time.

You learn specifically how to use sexual energy to increase vitality. Why?

Genital area is the most powerful center of energy in the human body. In Taoist teachings are three main centers of energy ("Tan Tien"): brain, heart and genitals. Each of these centers directs energy and distributes it throughout the body. Most people know how to make your brain work, but neglect the heart or sexuality. But the heart generates energy for longer-term.



When a person is happy or in love, it leads to a marked increase in vitality.



When a person has both love and orgasm, the vital energy reaches a peak. As for the sexual energy, it is so powerful and beneficial that Chinese medicine for thousands of years recommended for curing some diseases have sex in a certain position at a specific time to send a vitality to the sick body.