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Trade name:
Prozac
International name:
Fluoxetine
Group Affiliation:
Antidepressant
Description of the active substance (INN):
Fluoxetine
Dosage form:
Capsules
Pharmacological Effects:
Antidepressive tool, a selective serotonin reuptake inhibitors. It improves mood, reduces tension, anxiety and fear, eliminates dysphoria. Does not cause orthostatic hypotension, sedation, nekardiotoksichen. Persistent clinical effect occurs within 1-2 weeks of treatment.
Indications:
Depression (regardless of the degree of depressive disorder - weak, moderate, severe), bulimia, anorexia, alcoholism, obsessive-compulsive disorder.
Contraindications:
Hypersensitivity, renal failure (CC less than 10 ml / min), expressed liver failure, suicidal tendencies, simultaneous reception of MAO inhibitors (in the previous 2 weeks), pregnancy, laktatsii.C caution. Diabetes mellitus, epileptic syndrome of different genesis and epilepsy (including history), Parkinson's disease, compensated renal and / or hepatic failure, cachexia.
Side effects:
From the nervous system: dizziness, headache, drowsiness or insomnia, lethargy, fatigue, asthenia, tremor, agitation, anxiety, suicidal tendencies (typical of patients with major depressive disorder), mania or hypomania. From the digestive system: loss of appetite, dry mouth or hygrostomia, nausea, diarrhea. Allergic reactions: skin rash, urticaria. Other: increased sweating, weight loss, decreased libido, systemic violations of the lung, kidney or liver, vaskulity.Peredozirovka. Symptoms: nausea, vomiting, a state of excitation, convulsions. Treatment: gastric lavage, the appointment of activated charcoal, in convulsions - anxiolytic LAN (tranquilizers), symptomatic therapy.
Dosage and administration:
Inside, depression starting dose - 20 mg / day 1 time in the morning if necessary, increase the weekly dose of 20 mg / day. The maximum daily dose - 80 mg in 2-3 doses. With bulimia, and for elderly patients - 60 mg in 3 divided doses, with obsessive-compulsive disorder - 20-60 mg / day. Maintenance therapy - 20 mg / day. Course of treatment - 3-4 weeks.
Cautions:
When treating patients with underweight anorectics should take into account the effects of (possible progressive loss of body weight). In patients with diabetes mellitus appointment fluoxetine increases the risk of hypoglycemia and hyperglycemia - when its abolition. In connection with this dose of insulin and / or any other hypoglycemic LS used inside should be adjusted. Prior to the significant improvement in the treatment of patients should be under medical supervision. During treatment should refrain from receiving ethanol and occupations potentially hazardous activities that require attention and speed of mental and motor responses. The interval between the end of therapy inhibitors and the start of treatment with fluoxetine should be at least 14 days between the end of treatment with fluoxetine and starting therapy inhibitors - not less than 5 weeks. In liver and in old age, treatment should begin with 1 / 2 dose.
Interaction:
Enhance effects of alprazolam, diazepam, ethanol, and hypoglycemic LS. Increases in plasma concentration of phenytoin, tricyclic antidepressants, Maprotiline, trazodone 2-fold (to 50% lower dose of tricyclic antidepressants, while the application). Against the background of electroconvulsive therapy may develop prolonged seizures. Tryptophan enhances serotonergic properties of fluoxetine (increased agitation, restlessness, disorders of the gastrointestinal tract). MAO inhibitors increase the risk of serotonin syndrome (hyperthermia, chills, sweating, myoclonus, hyperreflexia, tremor, diarrhea, disturbances of coordination of movements, autonomic lability, agitation, delirium and coma). BOS, providing a depressing effect on the central nervous system, increase the risk of side effects and enhance the inhibitory effect on the central nervous system. In an application with the LS with a high degree of protein binding, especially with anticoagulants and digitoxin may increase plasma concentrations of free (unbound) medicines and an increased risk of adverse effects.
Description of the drug Prozac is not intended for purposes of treatment without the participation of a physician.
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